Rationale: The purpose of this application is to strengthen the tuberculosis (TB) translational research capacity at UCSF/SFGH by developing a BSL-3 laboratory in which work with human TB can be safely carried out in tissue culture and in small animal models.
An Open Proposal Opportunity
Proposals on Proposal
Less than 8% of orthopaedic research originates in low and middle income countries (LMICs), despite the fact that 95% of deaths from road traffic accidents occur in these countries. Global partners of the Institute for Global Orthopaedics and Traumatology (IGOT) have asked for assistance in building the capacity to perform clinical research. This is important because:
Rationale. Problem: because of multiscale complexity, conceptual, mechanism-based, in vitro-to-in vivo mapping models are hard to falsify and can be flawed in ways that may not be obvious until challenged experimentally, which can be costly. When the results of such experiments are equivocal or not supportive, the information needed to revise mechanistic hypotheses may be lacking. Translation of in vitro phenomena to in vivo counterparts requires a mapping model. Currently, mechanism-agnostic correlation models are common
RandomizationCentral.org: an open-source, web based randomization portal to support RCTs for the global research community
Rationale: An effective randomization system is crucial to the design, conduct, and analysis of any randomized controlled trial (RCT).
Extending Direct-to-Participant Recruitment on the Internet with Effective Online Self-Screening Eligibility Surveys
Rationale: Developing efficient and effective methods to recruit and screen participants for clinical research remains a major challenge for clinical discovery.
Rationale The Program in Implementation Science has created a series of courses within the Training in Clinical Research Program that are designed to meet the didactic training needs of fellows and junior faculty, but lacks an experiential component.
The Patient Centered Outcomes Research Institute is charged with facilitating informed choice by funding initiatives that create condition-specific registries designed to provide information necessary for patients to understand risks and expected benefits in terms of meaningful outcomes. Traditionally, registries require hiring personnel, not directly involved in the care of patients, to distribute surveys, review charts, fill in forms, and enter data into an offsite registry.