Osteoporosis is a highly prevalent disorder in older postmenopausal women both nationally and internationally, and a potent major risk factor for subsequent fracture. Among older women of white race, it is estimated that approximately 1 in 2 women will experience an osteoporotic fracture in her lifetime. Nationwide efforts during the past two decades have led to evidence-based consensus guidelines for osteoporosis screening and treatment, with the goal of both primary and secondary fracture risk reduction.
The Big Tent
CTSI 2016 NIH Renewal Proposal Launchpad
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The NIH grant awarded to the Clinical and Translational Science Institute (CTSI) must be recompeted in 2016, and the proposal planning process has begun. That includes using UCSF Open Proposals to solicit ideas for high-impact initiatives to include in the next 5-year CTSI grant. CTSI's goal is to involve the broadest community possible — the UCSF community, affiliate organizations, community partners, etc. — to help identify and plan activities that will substantially improve translational research at UCSF, regionally and nationally.
Open Proposals Awarded!: CTSI has selected 2 proposals for planning grants and 3 honorable mentions. The winning proposals are the first 2 proposals listed below, with the notation "Selected for Planning Grants". Thank you for your interest and participation in this "Open Proposal" opportunity.
How can we minimize our contributions to global warming in the operation of our CTSI and CTSA programs in general? An example of a high carbon activity are airplane flights. Are there ways to use alternative communication modalities to avoid taking more transcontinental flights than necessary for scientific meetings, administrative activities, etc? The challenge of this big tent proposal would be to perform an inventory of our CTSI carbon footprint and find ways to reduce it without compromising our programs.
Translating Neurobiological Knowledge into Psychosocial and Behavioral Interventions That can Prevent and Treat Stress-Related Illness
Problem: Rapidly progressive encephalopathies are diagnostically challenging and provide great potential for scientific and clinical advancement by harnessing the interdisciplinary resources and collaborative infrastructure of the CTSIs.We need systems to rapidly identify emerging infections and immunologically-mediated nervous system disorders and to investigate their causes and possible genetic contributors in order to provide rapid, efficient and cost-effective diagnosis, discover new diseases, and guide appropriate treatment.
Once considered rare, neurodegenerative diseases are now recognized as among the most common and devastating health problems of aging.
Adverse social circumstances like community violence, unstable housing, food deserts and poverty can have dramatic, negative impacts on the health of vulnerable children. In safety-net settings, the prevalence of these adverse social circumstances is alarmingly high.
The pace and efficiency of recruitment of participants into a study is typically the limiting factor for how quickly a clinical trial can be completed. Maximizing the efficiency and scale of recruitment for a study means the study can be completed sooner, use fewer resources, and/or increase the study’s sample size, and therefore its utility to science.
1. Scale and significance: Creative and groundbreaking T-2-T-3 Innovations in health care and community delivery have been developed and tested within many UCSF settings. While some successes have been achieved, the campus has not been able to leverage the full power of these innovations; limitations in the scalability of even the strongest and best-tested innovations occur.
Bay Area Nutrition and Health Initiative: A Novel Family and Community-Based Approach for Addressing the Gap Between Nutrition Science and Improvements in Nutrition-related Health Outcomes
Poor nutritional practices contribute inordinately to the major diseases affecting public health and hence the health care economy. Among these are obesity (recently classified as a disease in itself) as well as heart disease, hypertension, stroke, diabetes, and likely, some forms of cancer. While weight loss has been a focus of trials aimed at improving disease risk, studies such as the recent report of the NIH Look Ahead trial have failed to demonstrate that diet-induced weight loss reduces disease outcome (in this case, cardiovascular disease).
Improving Education and Treatment of Newborns with Disorders Detected in the California State Newborn Screening Program through Linking Resources of the CTSI with the State Genetic Disease Screening Program
The IOM has called for the CTSAs to expand research on children. The CTSI and the California Department of Public Health have a common vision of improving the health of children through newborn screening programs for genetic disorders. California has been a pioneer in developing new approaches to diagnosis, education, and treatment of disorders detected in the newborn period. Currently, several million newborns in California are screened for 21 genetic disorders each year.