Rationale Chlamydia trachomatis remains the most commonly reported bacterial sexually transmitted infection among U.S.
Rationale: Inaccurate sample size estimation leads to research studies that enroll too few or too many study participants. The former can result in failure to demonstrate anticipated effects and the latter to excessive costs, due to overuse of research participants and personnel time. While there are several important components of a good sample size calculation – including a compelling research question, an appropriate outcome variable, and an efficient study design – here we focus on improving the accuracy of the quantitative inputs.
Rationale: The purpose of this application is to strengthen the tuberculosis (TB) translational research capacity at UCSF/SFGH by developing a BSL-3 laboratory in which work with human TB can be safely carried out in tissue culture and in small animal models.
Rationale
Less than 8% of orthopaedic research originates in low and middle income countries (LMICs), despite the fact that 95% of deaths from road traffic accidents occur in these countries. Global partners of the Institute for Global Orthopaedics and Traumatology (IGOT) have asked for assistance in building the capacity to perform clinical research. This is important because:
Rationale. Problem: because of multiscale complexity, conceptual, mechanism-based, in vitro-to-in vivo mapping models are hard to falsify and can be flawed in ways that may not be obvious until challenged experimentally, which can be costly. When the results of such experiments are equivocal or not supportive, the information needed to revise mechanistic hypotheses may be lacking. Translation of in vitro phenomena to in vivo counterparts requires a mapping model. Currently, mechanism-agnostic correlation models are common
Rationale:
Rationale: An effective randomization system is crucial to the design, conduct, and analysis of any randomized controlled trial (RCT).
The Patient Centered Outcomes Research Institute is charged with facilitating informed choice by funding initiatives that create condition-specific registries designed to provide information necessary for patients to understand risks and expected benefits in terms of meaningful outcomes. Traditionally, registries require hiring personnel, not directly involved in the care of patients, to distribute surveys, review charts, fill in forms, and enter data into an offsite registry.