CTSI Annual Pilot Awards to Improve the Conduct of Research

An Open Proposal Opportunity

Proposals on Other

Broadband Multichannel Transmitters for Enhanced Metabolic MR Imaging

Submitted by Xiaoliang Zhang on February 27, 2012 - 10:21pm Last revised by Anonymous on May 2, 2014 - 12:08pm.
Type: 
Proposal
Topics: 
Other
Proposal Status: 
Final Proposal

1. Rationale

Surbeck Laboratory for advanced imaging at UCSF, is an interdepartmental and interdisciplinary laboratory that provides unique instrumentation, expertise, and infrastructure to enable the faculty, trainees and staff to carry out translational and clinical research utilizing the unique capabilities of high magnetic fields. Research at the Surbeck Lab has resulted in some of the most advanced MR instrumentation and expertise currently available and has been the source of critical technologies and methodologies in multiple areas of non-invasive biomedical research at cellular and molecular scale.

Mobile Study Support Pilot Project

Submitted by Mario Moreno on February 27, 2012 - 4:52pm Last revised by Anonymous on May 2, 2014 - 12:08pm.
Type: 
Proposal
Topics: 
Clinical Research
Early Translational Research
Other
Proposal Status: 
Final Proposal

Rationale: UCSF and the Benioff Children's Hospital have been selected by the national Children's Oncology Group Consortium (COG) of the National Cancer Institute (NCI) to conduct new Phase I Pediatric Oncology studies. Patients enrolled in these studies who are not admitted to the Pediatric Clinical Research Center (PCRC) Inpatient Unit, will require evening and weekend support for study procedures, including timed blood draws, sample processing and EKGs.

Developing and testing mechanism-based translational hypotheses

Submitted by C. Anthony Hunt on February 22, 2012 - 12:52pm Last revised by Anonymous on May 2, 2014 - 12:08pm.
Type: 
Proposal
Topics: 
Clinical Research
Early Translational Research
IT and Informatics
Other
Proposal Status: 
Final Proposal

Rationale.  Problem: because of multiscale complexity, conceptual, mechanism-based, in vitro-to-in vivo mapping models are hard to falsify and can be flawed in ways that may not be obvious until challenged experimentally, which can be costly.  When the results of such experiments are equivocal or not supportive, the information needed to revise mechanistic hypotheses may be lacking.  Translation of in vitro phenomena to in vivo counterparts requires a mapping model.  Currently, mechanism-agnostic correlation models are common