CTSI Annual Pilot Awards to Improve the Conduct of Research

An Open Proposal Opportunity

Proposals on Clinical Research

Developing and testing mechanism-based translational hypotheses

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RationaleProblem: because of multiscale complexity, conceptual, mechanism-based, in vitro-to-in vivo mapping models are hard to falsify and can be flawed in ways that may not be obvious until challenged experimentally, which can be costly.  When the results of such experiments are equivocal or not supportive, the information needed to revise mechanistic hypotheses may be lacking.  Translation of in vitro phenomena to in vivo counterparts requires a mapping model.  Currently, mechanism-agnostic correlation models are common

RandomizationCentral.org: an open-source, web based randomization portal to support RCTs for the global research community

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Rationale: An effective randomization system is crucial to the design, conduct, and analysis of any randomized controlled trial (RCT).

Extending Direct-to-Participant Recruitment on the Internet with Effective Online Self-Screening Eligibility Surveys

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Rationale: Developing efficient and effective methods to recruit and screen participants for clinical research remains a major challenge for clinical discovery.

Action Research Program

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Rationale The Program in Implementation Science has created a series of courses within the Training in Clinical Research Program that are designed to meet the didactic training needs of fellows and junior faculty, but lacks an experiential component.

Overcoming hurdles to patient-centered outcomes research

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The Patient Centered Outcomes Research Institute is charged with facilitating informed choice by funding initiatives that create condition-specific registries designed to provide information necessary for patients to understand risks and expected benefits in terms of meaningful outcomes. Traditionally, registries require hiring personnel, not directly involved in the care of patients, to distribute surveys, review charts, fill in forms, and enter data into an offsite registry.

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