An Open Proposal Opportunity
Proposals on Early Translational Research
Rationale: The confluence of online social media, smart phones, and sensor technology is giving rise to a tidal wave of digital health interventions that have vast potential for improving health at low cost. As with consumer software, digital interventions are more likely to be effective if user feedback and determination of effectiveness is sought early and often. At present, however, researchers face high costs and difficulty in developing app ideas into prototypes, testing prototypes on real users, and validating the intervention.
Rationale: The rapidly evolving field of digital health has great potential to enhance biomedical research, education and clinical care. Development in this new space is largely being driven by the tech sector, where projects may lack proper clinical focus or scientific rigor and generally do not include health outcome measures to assess effectiveness or impact.
Rationale: UCSF and the Benioff Children's Hospital have been selected by the national Children's Oncology Group Consortium (COG) of the National Cancer Institute (NCI) to conduct new Phase I Pediatric Oncology studies. Patients enrolled in these studies who are not admitted to the Pediatric Clinical Research Center (PCRC) Inpatient Unit, will require evening and weekend support for study procedures, including timed blood draws, sample processing and EKGs.
As a core pharmacology laboratory for Center for AIDS Research at UCSF, the Drug Research Unit (DRU) often encounters problems regarding column selection during memthod development. Here I propose to seek for funding to buy 25-50 analytical columns as a column kit for method development.
Rationale: Enrolling subjects for longitudinal research studies, ensuring their compliance and retaining them over a period of time pose a significant challenge to researchers. As an example, we had 62% and 30% retention at years 1 and 3 in a recently concluded study on knee osteoarthritis.
The Immunological Microbiome Project: Collaborative Microbial database for the prediction of disease and immunological research
Rationale – The mammalian gastrointestinal (GI) tract contains hundreds of distinct species of commensal microbes under normal conditions, referred to as the ‘microbiota’. Recently, it has been appreciated that the microbiota exists in a mutualistic relationship with the host immune system.
The Challenging Path from Bench to Bedside
Translating an Effective Systems-Based Chlamydia Screening Intervention For Australian General Practitioners in New South Wales
Rationale Chlamydia trachomatis remains the most commonly reported bacterial sexually transmitted infection among U.S.
Rationale: The purpose of this application is to strengthen the tuberculosis (TB) translational research capacity at UCSF/SFGH by developing a BSL-3 laboratory in which work with human TB can be safely carried out in tissue culture and in small animal models.