CTSI Annual Pilot Awards to Improve the Conduct of Research
An Open Proposal Opportunity
Rationale: The APEX system has been promoted to the faculty as providing a new and extremely valuable means of doing clinical research, especially for discovering previously unappreciated clinical associations such as the relationship of kidney stone and myocardial infarction, etc.. Such associations would be very valuable in discovering underlying mechanisms of disease. However, the APEX system falls very short of fulfilling this promise, because it has been primarily designed for maintaining information for medical practice, and for billing. The problem is that it forc
Rationale: The confluence of online social media, smart phones, and sensor technology is giving rise to a tidal wave of digital health interventions that have vast potential for improving health at low cost. As with consumer software, digital interventions are more likely to be effective if user feedback and determination of effectiveness is sought early and often. At present, however, researchers face high costs and difficulty in developing app ideas into prototypes, testing prototypes on real users, and validating the intervention.
Rationale: The rapidly evolving field of digital health has great potential to enhance biomedical research, education and clinical care. Development in this new space is largely being driven by the tech sector, where projects may lack proper clinical focus or scientific rigor and generally do not include health outcome measures to assess effectiveness or impact.
Rationale: UCSF and the Benioff Children's Hospital have been selected by the national Children's Oncology Group Consortium (COG) of the National Cancer Institute (NCI) to conduct new Phase I Pediatric Oncology studies. Patients enrolled in these studies who are not admitted to the Pediatric Clinical Research Center (PCRC) Inpatient Unit, will require evening and weekend support for study procedures, including timed blood draws, sample processing and EKGs.
Developing an administrative data system to investigate the social and health impacts of early childhood programs in San Francisco
Rational: There is extensive evidence of pervasive social disparities in health, many of which take root in early life. The importance of early childhood in setting the stage for future health and social outcomes is buttressed by rigorous scientific studies across disciplines. However, what remains less investigated is how well this knowledge has been translated to public agencies responsible for implementing early childhood programs and family support services.
As a core pharmacology laboratory for Center for AIDS Research at UCSF, the Drug Research Unit (DRU) often encounters problems regarding column selection during memthod development. Here I propose to seek for funding to buy 25-50 analytical columns as a column kit for method development.
Rationale: Enrolling subjects for longitudinal research studies, ensuring their compliance and retaining them over a period of time pose a significant challenge to researchers. As an example, we had 62% and 30% retention at years 1 and 3 in a recently concluded study on knee osteoarthritis.
Encouraging research collaboration and integrity by optimizing post-publication peer review for researcher participation
There is an integrity crisis in the life sciences.
The Immunological Microbiome Project: Collaborative Microbial database for the prediction of disease and immunological research
Rationale – The mammalian gastrointestinal (GI) tract contains hundreds of distinct species of commensal microbes under normal conditions, referred to as the ‘microbiota’. Recently, it has been appreciated that the microbiota exists in a mutualistic relationship with the host immune system.