Mobilization of Clinical Research Services (CRS) – Pilot Project
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CTSI sponsored awards of up to $50,000 to the UCSF Campus Community and CTSI Affiliate Organizations for ideas to improve the design, conduct, or analysis of translational research.
Four projects were awarded funding from among 27 proposals.
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RATIONALE: Realizing that the benefits of the current revolution in biology and oncology would be enhanced by vigorous public support, for the past twenty years, the UCSF Breast Oncology Program (BOP) has implemented comprehensive strategies focused on leveraging advocacy engagements.
Biobanking Inventory Software Evaluation
Rationale: Access to high quality human biospecimens and associated clinical data is essential to translational and clinical research programs. Effective and efficient use of human biospecimens is an important tenet of our role as community-entrusted stewards of these valuable resources. These points are reflective of the conclusions of the CTSI funded (2008-9) Tissue Task Force that engaged Huron Consulting as well as a recent 2011 audit of UCSF tissue banks by UCSF Audit Services.
Rationale – Background and training in bioinformatics tools is required for the research community at UCSF to remain at the forefront of biomedical research and successfully compete for funding. Bioinformatics tools help translate our collective molecular understanding of disease into actionable insights and life-improving patient care innovations.
Rationale: There are currently about 1000 mechanical – 80 degree Celsius freezers in use at UCSF. The majority of these freezers are used to store biomedical specimens for basic research, translational research, clinical trials, and prospective biobanking efforts.
Rationale:Taking findings from basic research to practical applications that enhance human health and well-being is the signification of translational research. Improvement in human health and well-being, however, does not necessarily involve the cure of a disease. Sometimes mere information transfer might help patients substantially in dealing with their medical condition. This is particularly true for patients with family history of yet unknown or contradictory diagnoses – in other words for patients with rare hereditary diseases.
Rationale: Each UC Biomedical campus contains tens to hundreds of biorepositories. These operations collect human biological samples (tissues and fluids) and associated data for use in research. UC biobanks traditionally have established their own governance structure, which includes rules for accessing, storing and sharing samples/data, including informed consent practices. Governance, a complicated process, has myriad ethical implications including risk to individuals, identifiability, and data sharing.
Rationale. Successful recruitment and retention of ethnically diverse research participants in clinical studies depends heavily on the comprehension, needs, and preferences of potential participants. A critical influence on these outcomes is health literacy, the degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.[i] Since 30% of US adults have only basic health literacy,
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