CTSI Annual Pilot Awards to Improve the Conduct of Research

An Open Proposal Opportunity

Most Commented Proposals

Extending Direct-to-Participant Recruitment on the Internet with Effective Online Self-Screening Eligibility Surveys

Type: 
Proposal Status: 

Rationale: Developing efficient and effective methods to recruit and screen participants for clinical research remains a major challenge for clinical discovery.

Action Research Program

Type: 
Proposal Status: 

Rationale The Program in Implementation Science has created a series of courses within the Training in Clinical Research Program that are designed to meet the didactic training needs of fellows and junior faculty, but lacks an experiential component.

Developing an administrative data system to investigate the social and health impacts of early childhood programs in San Francisco

Type: 
Proposal Status: 

Rational: There is extensive evidence of pervasive social disparities in health, many of which take root in early life. The importance of early childhood in setting the stage for future health and social outcomes is buttressed by rigorous scientific studies across disciplines. However, what remains less investigated is how well this knowledge has been translated to public agencies responsible for implementing early childhood programs and family support services.

Research Networking Software App/Gadget Development Competition

Type: 
Proposal Status: 

Background/Rationale: Social networking sites such as Facebook, Google+ and LinkedIn are web platforms. They allow independent applications to run within their sites to enhance the user experience, often integrating with external services to provide dynamic content as varied as reading lists from Amazon, blog posts from WordPress, to live game play from Zynga. The beauty of these external services is that they can be shared across any software platform that chooses to deploy them.

“Idea to Impact” (i2i): Translational Digital Health Program

Type: 
Proposal Status: 

Rationale: The rapidly evolving field of digital health has great potential to enhance biomedical research, education and clinical care. Development in this new space is largely being driven by the tech sector, where projects may lack proper clinical focus or scientific rigor and generally do not include health outcome measures to assess effectiveness or impact.

“Expedited” Expedited CHR submission and approval for Chart Review Research (Category 5)

Type: 
Proposal Status: 

Title: “Expedited” Expedited CHR submission and approval for Chart Review Research (Category 5)

 

Rationale: Clinical researchers often perform retrospective, chart-review studies as a relatively inexpensive and quick way of determining which clinical questions are worth pursuing before engaging in more expensive, time-consuming prospective studies.

 

A Clinical Research Toolkit for Surgeons in Low Resource Environments

Type: 
Proposal Status: 

Rationale

Less than 8% of orthopaedic research originates in low and middle income countries (LMICs), despite the fact that 95% of deaths from road traffic accidents occur in these countries.  Global partners of the Institute for Global Orthopaedics and Traumatology (IGOT) have asked for assistance in building the capacity to perform clinical research.  This is important because:

Developing and testing mechanism-based translational hypotheses

Type: 
Proposal Status: 

RationaleProblem: because of multiscale complexity, conceptual, mechanism-based, in vitro-to-in vivo mapping models are hard to falsify and can be flawed in ways that may not be obvious until challenged experimentally, which can be costly.  When the results of such experiments are equivocal or not supportive, the information needed to revise mechanistic hypotheses may be lacking.  Translation of in vitro phenomena to in vivo counterparts requires a mapping model.  Currently, mechanism-agnostic correlation models are common

Pages